Resource Library

Kiniksa is pleased to offer education resources for clinicians' personal use, to support you in understanding and managing recurrent pericarditis. You'll see a range of materials from clinical publications and slide programs to educational images.

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Educational Slide Presentations

Role of Interleukin-1 in Pathophysiology of Recurrent Pericarditis

This slide deck provides an overview of the role of interleukin-1 in the pathophysiology of recurrent pericarditis.

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Videos

The Role of Interleukin-1 in the Pathophysiology of Recurrent Pericarditis (4:43)

3D animated video

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Pathophysiology of Recurrent Pericarditis (1:19)

2D animated video

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Pathophysiology Images

Pathophysiology of Recurrent Pericarditis

8 scientific illustrations providing a step-by-step depiction of the IL-1–mediated autoinflammatory process that drives recurrent pericarditis

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IL-1α Image

Three-dimensional rendering of interleukin-1α cytokine

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IL-1β Image

Three-dimensional rendering of interleukin-1β cytokine

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Active IL-1α and IL-1β Binding to Receptor

Schematic illustration of active IL-1α and IL-1β binding to the IL-1 receptor

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Blocking IL-1 Signaling

Schematic diagram of the 3 known approaches to IL-1 signal blocking:
 

  • IL-1 receptor antagonist
  • Anti-IL-1β monoclonal antibody
  • IL-1 decoy receptor (trap)
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Anatomical Heart

Black-and-white flat images of an anatomical heart

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Molecular Images

Three-dimensional representations of an antibody and bacteria/viral antigen

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References and Citations

The following references were used in the creation of this web content. Click the
button next to the citation to gain access to each article, poster, or website.

2015 ESC Guidelines for the Diagnosis and Management of Pericardial Diseases: The Task Force for the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology (ESC).

Adler Y, Charron P, Imazio M, et al.
Eur Heart J. 2015;36(42):2921-2964.

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Recurrent Pericarditis: Still Idiopathic? The Pros and Cons of a Well-Honoured Term.

Brucato A, Imazio M, Cremer PC, et al.
Intern Emerg Med. 2018;13(6):839-844.

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Acute Pericarditis-Associated Hospitalization in the USA: a Nationwide Analysis, 2003-2012.

Kumar N, Pandey A, Jain P, Garg N.
Cardiology. 2016;135(1):27-35.

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Azathioprine: Old Drug, New Actions.

Maltzman JS, Koretzky GA.
J Clin Invest. 2003;111(8):1122-1124.

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Colchicine Administered in the First Episode of Acute Idiopathic Pericarditis: a Randomized Multicenter Open-label Study.

Sambola A, Roca Luque I, Mercé J, et al.
Rev Esp Cardiol (Engl Ed). 2019;72(9):709-716.

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Complicated Pericarditis: Understanding Risk Factors and Pathophysiology to Inform Imaging and Treatment.

Cremer PC, Kumar A, Kontzias A, et al.
J Am Coll Cardiol. 2016;68(21):2311-2328.

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Current US Population.

US Census Bureau.

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FDA Drug Safety Communication: FDA Strengthens Warning That Non-Aspirin Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Can Cause Heart Attacks or Strokes.

US Food and Drug Administration. July 9, 2015. Updated February 26, 2018. Accessed April 14, 2020.

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Health-Related Quality of Life of Patients With Recurrent Pericarditis in the United States.

LeWinter MM, Kontzias A, Lin D, et al. Poster presented at: Virtual ISPOR 2020; May 18-20, 2020. Poster PCV77.

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Interleukins (from IL-1 to IL-38), Interferons, Transforming Growth Factor ß, and TNF-α: Receptors, Functions, and Roles in Diseases.

Akdis M, Aab A, Altunbulakli C, et al.
J Allergy Clin Immunol. 2016;138(4):984-1010.

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Interleukin-1 Blockade for the Treatment of Pericarditis.

Buckley LF, Viscusi MM, Van Tassel BW, Abbate A.
Eur Heart J Cardiovasc Pharmacother. 2018;4(1):46-53.

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Interleukin-1 in the Pathogenesis and Treatment of Inflammatory Diseases.

Dinarello CA. Blood. 2011;117(14):3720-3732.

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Intravenous Immunoglobulin as Clinical Immune-Modulating Therapy.

Gilardin L, Bayry J, Kaveri SV. CMAJ. 2015;187(4):257-264.

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Management of Acute and Recurrent Pericarditis.

Chiabrando JG, Bonaventura A, Vecchie A, et al.
J Am Coll Cardiol. 2020;75(1):76-92.

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Myopericarditis Versus Viral or Idiopathic Acute Pericarditis.

Imazio M, Cecchi E, Demichelis B, et al. Heart. 2008;94(4):498-501.

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Pericarditis.

Cleveland Clinic website. March 12, 2020. Accessed April 14, 2020.

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Quantitative Assessment of Pericardial Delayed Hyperenhancement Helps Identify Patients With Ongoing Recurrences of Pericarditis.

Kumar A, Sato K, Verma BR, et al.
Open Heart. 2018;5(2):e000944.

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Quantitative Pericardial Delayed Hyperenhancement Informs Clinical Course in Recurrent Pericarditis.

Kumar A, Sato K, Yzeiraj E, et al.
JACC Cardiovasc Imaging. 2017;10(11):1337-1346.

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Real-World Clinical Characteristics and Recurrence Burden of Patients Diagnosed With Recurrent Pericarditis in the United States.

Lin D, Majeski C, DerSarkissian M, et al. Poster presented at: American Heart Association (AHA) Scientific Sessions 2019; November 16-18, 2019; Philadelphia, PA. Poster Su3090.

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Recurrence Burden in Recurrent Pericarditis: a US-Based Retrospective Study of Administrative Healthcare Claims.

Lin D, Laliberte F, Magestro M, et al. Poster presented at: American Heart Association Quality of Care and Outcomes Research 2020 Scientific Sessions; Virtual Meeting; May 15-16, 2020. Poster 248.

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Recurrent Pericarditis.

Imazio M, Battaglia A, Gaido L, Gaita F. Rev Med Interne. 2017;38(5):307-311.

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Recurrent Pericarditis Epidemiology in the United States (2013-2018).

Klein A, Cremer P, Kontzias A, et al. Poster presented at: American College of Epidemiology (ACE) 2019 Annual Meeting; September 7-10, 2019; Pasadena, CA. Poster P13.

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Recurrent Pericarditis: New and Emerging Therapeutic Options.

Imazio M, Lazaros G, Brucato A, Gaita F.
Nat Rev Cardiol. 2016;13(3):99-105.

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Targeting the Interleukin-1 Pathway in Patients With Hematological Disorders.

De Mooij CEM, Netea MG, van der Velden WJFM, Blijlevens NMA. Blood. 2017;129(24):3155-3164.

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Treating Inflammation by Blocking Interleukin-1 in a Broad Spectrum of Diseases.

Dinarello CA, Simon A, van der Meer JW.
Nat Rev Drug Discov. 2012;11(8):633-652.

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Treating Inflammation by Blocking Interleukin-1 in Humans.

Dinarello CA, van der Meer JW.
Semin Immunol. 2013;25(6):469-484.

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Trends in Acute Pericarditis Hospitalizations and Outcomes Among the Elderly in the USA, 1999-2012.

Mody P, Bikdeli B, Wang Y, Imazio M, Krumholz HM. Eur Heart J Qual Care Clin Outcomes. 2018;4(2):98-105.

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Unmet Needs & Burden of Recurrent Pericarditis (RP): Results of a Systematic Literature Review (SLR).

Crotty C, Forsythe A, Magestro M. Poster presented at: International Society for Pharmacoeconomics and Outcomes Research (ISPOR) 2019 Annual Meeting; May 18-22, 2019; New Orleans, LA. Poster PCV9.

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